My current work involves using sequence based models to learn about how post-transcriptional regulation may affect RNA stability. A major theme is trying to understand the contributions and interactions between different regulatory mechanisms in a cell-type specific way.
I’m also working to develop methods to study ancient migration events using contemporary genomes. For more information, check out smcsmc.
@ London School of Hygiene and Medicine (Frank Dudbridge)
Building on the idea that a single polygenic risk score may not capture all relevant information, I continued the work of my undergraduate thesis and developed a cardiometabolic risk score for the prediction of various complex traits. I also worked on the theoretical properties of optimal disovery procedure (ODP), a relatively recent framework for multiple testing correction.
@ University of Toronto, Lancaster University (Jo Knight)
I also collaborated with Nuwan Hettige to construct a polygenic risk score for anti-psychotic dosage and with Meghan Chenoweth to perform a GWAS for NMR, a biomarker for nicotine metabolism.
@ University of Ottawa Heart Institute (Ruth McPherson)
I worked alongside Dr. Majid Nikpay to construct polygenic risk scores for dyslipidedmia and found them to be significantly altered by adiposity. Additionally used a Mendelian randomization study to find links between Coronary Artery Disease aetiology and obesity.
My thesis focused on combining polygenic risk scores across different predisposing conditions to create a master score which would be more predictive than its constituents. This was formalized when in London with Frank Dudbridge.
@ University of Ottawa (Stephane Aris-Brosou)
I designed and implemented a rejection sampler to determine phylogeny topology in viral evolution. And started learning